Description
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Chemical Name: 2-Fluorodeschloroketamine
Common Abbreviation: 2-FDCK
Chemical Class: Arylcyclohexylamine derivative
Structural Relation: Fluorinated analog of deschloroketamine; structurally related to Ketamine
Pharmacological Category: Dissociative anesthetic (research classification)
Physical Property
| Parameter | Typical Description (Literature/Analytical Reference) | Common Analytical Method |
|---|---|---|
| Chemical Class | Arylcyclohexylamine derivative | Structural classification |
| Molecular Formula | C₁₃H₁₆FNO | Elemental analysis |
| Molecular Weight | ~221.27 g/mol | Calculated molecular mass |
| Physical State | Solid | Visual inspection |
| Appearance | White to off-white crystalline powder | Visual inspection |
| Odor | Typically odorless or faint chemical odor | Sensory observation (controlled lab setting) |
| Solubility (Water) | Limited to moderate solubility | Solubility testing |
| Solubility (Ethanol) | Soluble | Laboratory solubility test |
| Solubility (DMSO) | Highly soluble | Laboratory solubility test |
| Melting Point | Approximately 150–160 °C* | Differential Scanning Calorimetry (DSC) |
| Stability | Sensitive to moisture and prolonged light exposure | Stability testing |
| Structural Confirmation | Characteristic arylcyclohexylamine backbone | NMR / FTIR |
| Mass Spectrum | Fluorinated fragment pattern consistent with structure |
Chemical Assay & Purity Profiling
| Test Parameter | Purpose | Typical Specification Framework* | Common Analytical Method |
|---|---|---|---|
| Identity Confirmation | Confirms molecular structure | Must match certified reference standard | NMR (¹H / ¹³C), FTIR |
| Active Compound Assay | Determines quantitative purity | ≥ 98–99% (research-grade benchmark) | HPLC-UV or HPLC-DAD |
| Related Arylcyclohexylamine Analogues | Detects structurally similar impurities | ≤ 0.5–1.0% (typical research limit) | HPLC-MS / LC-MS/MS |
| Unknown Organic Impurities | Screens non-target organic residues | ≤ 0.5% cumulative (general research benchmark) | GC-MS |
| Residual Solvents | Detects leftover synthesis solvents | ICH Q3C compliant limits | Headspace GC |
| Heavy Metals | Screens toxic elemental contamination | ≤ 10 ppm (research-grade reference threshold) | ICP-MS |
| Moisture Content | Measures water content | ≤ 0.5% (hygroscopic stability control) | Karl Fischer Titration |
| Total Ash Content | Detects inorganic residues | ≤ 0.2% (general lab reference) | Gravimetric analysis |
| Chromatographic Purity Profile | Establishes impurity distribution pattern | Retention time consistent with reference | HPLC-DAD |
Pharmacological Effects
- Dissociation
- Sedation
- Perceptual alteration
- Cognitive impairment
- Reduced motor coordination
2-Fluorodeschloroketamine Half-Life
- Estimated elimination half-life: approximately 6–12 hours (provisional range)
- Likely longer than ketamine due to fluorine substitution affecting metabolic stability
- Active metabolites may contribute to prolonged subjective effects
Pharmacokinetic Considerations
- Metabolism: Presumed hepatic metabolism (likely CYP450-mediated oxidation and demethylation, extrapolated from arylcyclohexylamine class data)
- Accumulation risk: Possible with repeated exposure due to moderate half-life
- Excretion: Primarily renal (metabolites)
Packaging & Compliance
- Moisture-barrier container
- Tamper-evident seal
- Controlled access storage
Transport compliance, where legally permitted, aligns with guidance from the International Air Transport Association (air freight) and the International Maritime Organization (sea freight).
Martin K. –
I recently ordered a batch of 2-FDCK (2-Fluorodeschloroketamine) | CAS No.: 111982-50-4 for our laboratory in Estonia, and the experience has been flawless from start to finish.
Sourcing specialized chemical reagents from the Baltics can often come with logistical bottlenecks and customs delays. However, China Chem Supplies handled the international shipping perfectly. The parcel arrived here in Estonia much faster than expected, packaged securely, and with completely discreet labeling that ensured smooth clearance.
The quality of the compound itself is outstanding. The product arrived as a pristine, high-purity crystalline powder. Our analytical testing (HPLC) confirmed a purity profile exceeding 99%, with no unexpected structural anomalies or residual impurities. The batch’s excellent stability has allowed us to conduct our in vitro binding assays with the highest level of data precision and reproducibility.
Finding a reliable B2B supplier that understands both analytical standards and European logistics is rare. China Chem Supplies has earned our trust, and we look forward to a long-term purchasing partnership.
Suur tänu suurepärase kvaliteedi eest!
Best regards,
Martin K.
Lead Analytical Chemist | Tallinn, Estonia