Description
4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine), also known as metocin, is a synthetic psychedelic compound belonging to the tryptamine class. Structurally, it is closely related to psilocin and other 4-substituted tryptamines.
Buy 4-HO-MET
- Chemical Class: Substituted tryptamine
- Form: Crystalline or Amorphous powder
- Pharmacological category: Classical serotonergic psychedelic
Mechanism of Action
4-HO-MET acts primarily as a partial agonist at serotonin (5-hydroxytryptamine) receptors, particularly:
- 5-HT₂A (primary psychoactive mechanism)
- 5-HT₂C
- 5-HT₁A (to a lesser extent)
Primary Mechanism — 5-HT₂A Activation
The compound binds to 5-HT₂A receptors located densely in the cerebral cortex, especially in layer V pyramidal neurons. Activation of these receptors:
- Increases glutamate release in cortical circuits
- Enhances excitatory signaling
- Disrupts normal thalamocortical sensory gating
- Alters perception, cognition, and mood
This receptor interaction is the core mechanism responsible for psychedelic effects.
Physical Properties
| Parameter | Specification / Description | Technical Notes |
|---|---|---|
| Appearance | Off-white to light beige crystalline powder | May darken upon oxidation |
| Physical State | Solid (crystalline or amorphous powder) | Hygroscopic under humid conditions |
| Molecular Weight | 218.30 g/mol | Free base form |
| Melting Point | ~140–155°C (reported range) | May vary depending on salt form |
| Solubility (Water) | Slightly soluble | Increased solubility in acidic conditions |
| Solubility (Organic Solvents) | Soluble in ethanol, methanol, DMSO | Common analytical solvents |
| LogP (Estimated) | Moderate lipophilicity | Facilitates blood–brain barrier crossing |
| Stability | Sensitive to heat, light, oxygen, moisture | Indole oxidation risk |
| Odor | Generally odorless | Typical of tryptamine derivatives |
Chemical Properties
| Parameter | Value / Description | Technical Notes |
|---|---|---|
| IUPAC Name | 3-[2-(ethyl(methyl)amino)ethyl]-1H-indol-4-ol | Systematic nomenclature |
| Molecular Formula | C₁₃H₁₈N₂O | Free base |
| Chemical Class | Substituted tryptamine | 4-hydroxy tryptamine subgroup |
| Functional Groups | Indole ring, tertiary amine, phenolic hydroxyl (-OH) | Hydroxy group affects stability |
| pKa (Estimated) | ~9–10 (amine group) | Weak base |
| UV Absorption | Strong absorbance ~220–280 nm | Used in HPLC-UV detection |
| Oxidation Sensitivity | Moderate to high | Indole and phenolic group prone to degradation |
| Salt Forms | Commonly encountered as fumarate salt | Improves stability and handling |
| Storage Conditions | Cool, dry, light-protected, airtight container | Preferably refrigerated or frozen |
China Chem Supplies
We provide comprehensive chemical logistics services designed to streamline procurement, storage, and distribution. Our facilities support temperature-sensitive materials, hazardous classifications, and secure inventory management systems.
Each shipment is managed through a structured compliance process to meet domestic and international transport requirements. By combining logistics planning with regulatory oversight, we minimize delays and maximize operational efficiency. Partner with a team that understands the complexity of chemical supply chains and delivers consistent, compliant performance.
Packaging & Export Compliance
Packaging conforms to international chemical export transport standards including:
- Aluminum moisture-barrier packaging
- Tamper-evident sealing
- Anti-static protective containment
Shipping compliance aligns with regulations from the International Air Transport Association for air freight and International Maritime Organization for sea freight.
This product is intended for laboratory research, analytical reference, or industrial testing purposes only, subject to the import and chemical control laws of the destination country.
Philip –
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